- Fatjohn (voiced by John Brimm) - the main character. He is a trucker in his forties who works for James Randall Trucking.
- Frederick Kalgarron (voiced by Curtis Kilprus) - Fatjohn's passenger from Fatjohn, Frederick, & James. He is a trucker who now drives his own truck. He has brown hair and green eyes.
- Kenneth "Kenny" Orange (voiced by Curtis Kilprus) - Fatjohn's younger son. He has light brown hair and blue eyes. He is known for his complaining.
- John Orange, Jr. (voiced by Kyle Kipperstone) - John Junior is Fatjohn's older son. He is named after his father. He is less childish than his brother Kenny. John Junior is a middle-school student who stands at 5'7".
- Parker Stuart (voiced by Kyle Kipperstone) - a blond-haired, green-eyed trucker in his twenties. He stands at 5'9" and is known for his somewhat high voice and love for "speeding".
- Jett Royle (voiced by Rohn Goss) - a blond-haired, blue-eyed man in his twenties. He stands at 5'8" and is known for speaking with a soft voice.
- Big Zonie (voiced by Gabe McPunnitt) - Big Zonie, whose real name is Zonapath Matthews, is a trucker who speaks with an Australian accent. He has black hair, and is balding. Big Zonie has green eyes. He stands at 6', and, like James, he frequently belches.
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